Aboard the ship Advenna Avis in 1711, a group of alchemists summon a demon in the hopes of gaining eternal life. The demon gives them an elixir of immortality and the method of ending their existence, by "devouring" one another, and grants the summoner Maiza Avaro the formula of the elixir. Most of the alchemists decide that no one else must become immortal; only Szilard opposes. The next night, the alchemists begin to disappear, devoured by Szilard. Realizing the threat posed by staying together, they scatter across the globe.In New York City during November 1930, Szilard succeeds in recreating the elixir, only to have it stolen by young thug Dallas. The elixir continually moves around the city unknown to the people that have it of its power. Firo and his Camorra family, the Martillo, and Isaac and Miria accidentally consume the elixir. Firo falls in love with Szilard's homunculus, Ennis. After she betrays Szilard by telling Firo how to devour Szilard.In late 1931, the Gandor fight the Runorata family for control of the same area. In an attempt to resolve the situation, Luck Gandor asks his adoptive brother Claire Stanfield, the legendary assassin, to travel to New York. Claire agrees to and boards the transcontinental train. The train is hijacked by the Russo and Lemure gangs, and a battle ensues between the two gangs. Meanwhile, Jacuzzi Splot, Nice Holystone and their gang attempt to protect the passengers and fight the hijackers.
