Looking forward to Guild Wars 2, Star Wars: The Old Republic (mainly because I want something to do with my dad), and/or TERA. At least for MMOs.
Also waiting for Brink, Gears of War 3, Mass Effect 3, Dragon Age 2 (Totally going to be a mage this time, warriors are Fcking boring), and Skyrim.
I may also consider the next PSP system since I'm tired of missing those good PSP exclusive titles, but price is always... Maybe the regular ones will go on sale then.